Motif ID: ELK1,4_GABP{A,B1}.p3

Z-value: 3.978


Transcription factors associated with ELK1,4_GABP{A,B1}.p3:

Gene SymbolEntrez IDGene Name
ELK1 2002 ELK1, member of ETS oncogene family
ELK4 2005 ELK4, ETS-domain protein (SRF accessory protein 1)
GABPA 2551 GA binding protein transcription factor, alpha subunit 60kDa
GABPB1 2553 GA binding protein transcription factor, beta subunit 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
GABPAchr21_+_260296020.794.8e-04Click!
GABPB1chr15_-_484346410.685.6e-03Click!
ELK4chr1_-_2038674020.515.2e-02Click!
ELK1chrX_-_473949370.146.3e-01Click!


Activity profile for motif ELK1,4_GABP{A,B1}.p3.

activity profile for motif ELK1,4_GABP{A,B1}.p3


Sorted Z-values histogram for motif ELK1,4_GABP{A,B1}.p3

Sorted Z-values for motif ELK1,4_GABP{A,B1}.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of ELK1,4_GABP{A,B1}.p3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr15_+_72620570 3.332 NM_006465
 ARID3B
AT rich interactive domain 3B (BRIGHT-like)
chr22_+_20350272 3.041 NM_014337
NM_148175
NM_148176
 PPIL2


peptidylprolyl isomerase (cyclophilin)-like 2


chr17_+_4784524 2.807 RNF167
ring finger protein 167
chr16_+_65783571 2.592 E2F4
E2F transcription factor 4, p107/p130-binding
chr16_+_65783528 2.562 NM_001950
 E2F4
E2F transcription factor 4, p107/p130-binding
chr19_-_17349096 2.545 NM_031310
 PLVAP
plasmalemma vesicle associated protein
chr12_+_118590039 2.229 NM_006253
 PRKAB1
protein kinase, AMP-activated, beta 1 non-catalytic subunit
chr16_-_48960186 2.207 NM_001173984
NM_013263
 BRD7

bromodomain containing 7

chr12_-_47698781 2.158 NM_002733
NM_212461
 PRKAG1

protein kinase, AMP-activated, gamma 1 non-catalytic subunit

chr16_+_65783599 2.148 E2F4
E2F transcription factor 4, p107/p130-binding
chr17_-_71017509 2.107 NM_001142643
 CASKIN2
CASK interacting protein 2
chr2_+_169367345 1.999 NM_001039724
NM_001171632
NM_052946
 NOSTRIN


nitric oxide synthase trafficker


chr22_-_17798998 1.991 HIRA
HIR histone cell cycle regulation defective homolog A (S. cerevisiae)
chr2_+_33514896 1.951 NM_170672
 RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr1_+_36169260 1.932 NM_024852
NM_177422
 EIF2C3

eukaryotic translation initiation factor 2C, 3

chr16_-_1999760 1.930 NM_178167
 ZNF598
zinc finger protein 598
chr2_-_74915722 1.873


chr9_-_122595475 1.860 NM_012164
 FBXW2
F-box and WD repeat domain containing 2
chr2_+_128565269 1.765 UGGT1
UDP-glucose glycoprotein glucosyltransferase 1
chr6_-_168219380 1.734 NM_001122841
 FRMD1
FERM domain containing 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 184 entries
enrichment   p-value GO term description
2.53 2.96e-05 GO:0006521 regulation of cellular amino acid metabolic process
2.47 1.04e-05 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
2.47 1.04e-05 GO:0072395 signal transduction involved in cell cycle checkpoint
2.47 1.04e-05 GO:0072401 signal transduction involved in DNA integrity checkpoint
2.47 1.04e-05 GO:0072404 signal transduction involved in G1/S transition checkpoint
2.47 1.04e-05 GO:0072413 signal transduction involved in mitotic cell cycle checkpoint
2.47 1.04e-05 GO:0072422 signal transduction involved in DNA damage checkpoint
2.47 1.04e-05 GO:0072431 signal transduction involved in mitotic cell cycle G1/S transition DNA damage checkpoint
2.47 1.04e-05 GO:0072474 signal transduction involved in mitotic cell cycle G1/S checkpoint
2.43 4.64e-06 GO:0051436 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
2.41 1.50e-05 GO:0071158 positive regulation of cell cycle arrest
2.41 1.16e-03 GO:0050434 positive regulation of viral transcription
2.40 4.78e-07 GO:0000216 M/G1 transition of mitotic cell cycle
2.39 8.58e-06 GO:0031571 mitotic cell cycle G1/S transition DNA damage checkpoint
2.35 1.17e-05 GO:0051437 positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
2.34 1.56e-06 GO:0031145 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
2.32 4.91e-06 GO:0051439 regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
2.32 2.76e-05 GO:0051352 negative regulation of ligase activity
2.32 2.76e-05 GO:0051444 negative regulation of ubiquitin-protein ligase activity
2.32 2.90e-02 GO:0006369 termination of RNA polymerase II transcription

Gene overrepresentation in compartment category:

Showing 1 to 20 of 58 entries
enrichment   p-value GO term description
2.76 4.21e-03 GO:0044452 nucleolar part
2.57 2.82e-10 GO:0071013 catalytic step 2 spliceosome
2.49 1.14e-02 GO:0030532 small nuclear ribonucleoprotein complex
2.39 6.28e-06 GO:0000502 proteasome complex
2.29 3.59e-12 GO:0005681 spliceosomal complex
2.03 1.56e-03 GO:0022626 cytosolic ribosome
2.00 2.10e-02 GO:0015934 large ribosomal subunit
1.98 1.38e-03 GO:0000790 nuclear chromatin
1.97 8.16e-28 GO:0030529 ribonucleoprotein complex
1.97 2.27e-02 GO:0044450 microtubule organizing center part
1.90 8.44e-06 GO:0000151 ubiquitin ligase complex
1.89 7.86e-08 GO:0005840 ribosome
1.87 1.84e-04 GO:0016607 nuclear speck
1.80 1.52e-18 GO:0005730 nucleolus
1.79 1.48e-07 GO:0016604 nuclear body
1.79 8.90e-05 GO:0044445 cytosolic part
1.70 4.81e-04 GO:0044454 nuclear chromosome part
1.63 4.39e-04 GO:0000228 nuclear chromosome
1.56 8.11e-37 GO:0031981 nuclear lumen
1.55 5.43e-43 GO:0044428 nuclear part

Gene overrepresentation in function category:

Showing 1 to 20 of 40 entries
enrichment   p-value GO term description
1.97 1.13e-04 GO:0008026 ATP-dependent helicase activity
1.97 1.13e-04 GO:0070035 purine NTP-dependent helicase activity
1.96 1.83e-03 GO:0008565 protein transporter activity
1.87 1.61e-05 GO:0003735 structural constituent of ribosome
1.86 7.29e-05 GO:0004386 helicase activity
1.86 3.60e-02 GO:0008135 translation factor activity, nucleic acid binding
1.74 3.46e-06 GO:0004842 ubiquitin-protein ligase activity
1.70 4.95e-02 GO:0051082 unfolded protein binding
1.68 2.22e-05 GO:0019787 small conjugating protein ligase activity
1.68 1.84e-03 GO:0008168 methyltransferase activity
1.63 6.33e-03 GO:0016741 transferase activity, transferring one-carbon groups
1.62 6.80e-19 GO:0003723 RNA binding
1.54 1.77e-03 GO:0016881 acid-amino acid ligase activity
1.52 2.37e-03 GO:0042623 ATPase activity, coupled
1.51 3.09e-02 GO:0003713 transcription coactivator activity
1.48 5.50e-03 GO:0016879 ligase activity, forming carbon-nitrogen bonds
1.45 4.13e-03 GO:0016887 ATPase activity
1.41 1.46e-03 GO:0016874 ligase activity
1.38 4.99e-02 GO:0003712 transcription cofactor activity
1.37 2.41e-02 GO:0004674 protein serine/threonine kinase activity